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Although Simon practices safe sex all the time, he immediately panics when his girlfriend of the moment, Sandra, confesses to him that she has an STD the next morning after they had sex together. Meanwhile, Martin and Mac catch Ruthie's boyfriend, Vincent on a date with another girl and try to figure out a way to tell her the bad news to Ruthie. Also, Matt, Lucy, Kevin and Ruthie have second thoughts about telling Eric and Annie that Mary is not pregnant again, but in fact has decided to desert her husband Carlos and her baby son Charles and is getting a divorce. Lastly, Annie decides to go to New York to pay Mary a visit, but does not yet know about the whole situation.

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